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Article

Thrombin-dependent MMP-2 activity is regulated by heparan sulfate.

The Journal of biological chemistry - 31 Dec 2010

Koo Bon-Hun, Han Jung Ho, Yeom Young Il, Kim Doo-Sik

Abstract excerpt

Like most metalloproteases, matrix metalloprotease 2 (MMP-2) is synthesized as a zymogen. MMP-2 propeptide plays a role in inhibition of catalytic activity through a cysteine-zinc ion pairing, disruption of which results in full enzyme activation. A variety of proteases have been shown to be invo...

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Identifiers

PMID: 21041295
DOI: 10.1074/jbc.M110.171595
PMCID: PMC3009852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21041295-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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