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Article

Thrombospondin Type 1 Repeats Interact with Matrix Metalloproteinase 2

1 Oct 2000

Abstract excerpt

Thrombospondins are thought to function as inhibitors of angiogenesis. However, the mechanism(s) of this activity is not well understood. In this study, we have used the yeast two-hybrid system to identify proteins that interact with the thrombospondins 1 (TSP1) and 2 (TSP2) properdin-like type 1 repeats (TSR). One of the proteins identified that interacted with both TSR was matrix metalloproteinase 2 (MMP2). The...

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PMID: 10900205
DOI: 10.1074/jbc.m003834200

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