Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2.

Circulation research - 20 Feb 2004

Chua Ceres C, Rahimi Nader, Forsten-Williams Kimberly, Nugent Matthew A

Abstract excerpt

Fibroblast growth factor-2 (FGF2) activates the extracellular signal-regulated kinases 1 and 2 (ERK1/2) through its specific receptors. Interaction of FGF2 with cell-surface heparan sulfate proteoglycans has also been suggested to induce intracellular signals. Thus, we investigated whether FGF2 can stimulate ERK1/2 activation through heparan sulfate proteoglycans using mechanisms that do not depend on receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deoxyadenosines
Share to Fibroblast Growth Factor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 10

Share to Heparan Sulfate Proteoglycans

Share to Heparin-binding EGF-like Growth Factor

Share to Heparitin Sulfate

Share to Polysaccharide-Lyases

Share to Receptor, Fibroblast Growth Factor, Type 1

Source

Identifiers

PMID: 14684627
DOI: 10.1161/01.RES.0000112965.70691.AC

Genes

FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2.PMID 14684627Read ↗

Heparan sulfate proteoglycans.Semantic proximity Read ↗

Receptor specificity of the fibroblast growth factor family.Semantic proximity Read ↗

Heparan sulfate regulates the anabolic activity of MC3T3-E1 preosteoblast cells by induction of Runx2.Semantic proximity Read ↗

The proliferative and migratory activities of breast cancer cells can be differentially regulated by heparan sulfates.Semantic proximity Read ↗

Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans.Semantic proximity Read ↗

Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies.Semantic proximity Read ↗

Syndecan-2 is essential for angiogenic sprouting during zebrafish development.Semantic proximity Read ↗

Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells.Semantic proximity Read ↗

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity.Semantic proximity Read ↗

Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor.Semantic proximity Read ↗

Secreted Proteoglycans Directly Mediate Human Embryonic Stem Cell-Basic Fibroblast Growth Factor 2 Interactions Critical for ProliferationSemantic proximity Read ↗

FGF signals for cell proliferation and migration through different pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.