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Article

VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.

Neuron - 4 Nov 2010

Liu Yang, Abdel Samad Omar, Zhang Ling, Duan Bo, Tong Qingchun, Lopes Claudia, Ji Ru-Rong, Lowell Bradford B, Ma Qiufu

Abstract excerpt

Itch can be suppressed by painful stimuli, but the underlying neural basis is unknown. We generated conditional null mice in which vesicular glutamate transporter type 2 (VGLUT2)-dependent synaptic glutamate release from mainly Nav1.8-expressing nociceptors was abolished. These mice showed deficits in pain behaviors, including mechanical pain, heat pain, capsaicin-evoked pain, inflammatory pain, and neuropathic...

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Identifiers

PMID: 21040853
DOI: 10.1016/j.neuron.2010.09.008
PMCID: PMC2991105

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