Article

Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itch

2023-07-10

Abstract excerpt

Mouse models that combine tetracycline-controlled gene expression systems and conditional genetic activation can tightly regulate transgene expression in discrete cell types and tissues. However, the commonly used Tet-Off variant, tetracycline transactivator (tTA), when overexpressed and fully active, can lead to developmental lethality, disease, or more subtle behavioral phenotypes. Here we describe a profound it...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8170a730-cb77-5258-b502-6ccbe09146c5
DOI: 10.1101/2023.07.09.548214

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tetracycline transactivator overexpression in keratinocytes triggers a TRPV1 primary sensory neuron-dependent neuropathic itchDOI 10.1101/2023.07.09.548214Read

Mouse behavioral genomics identifies Creld1 as a gatekeeper of somatosensationSemantic proximity Read

Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsivenessSemantic proximity Read

Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor functionSemantic proximity Read

Piezo2 channel–Merkel cell signaling modulates the conversion of touch to itchSemantic proximity Read

Presynaptic inhibition of cutaneous afferents prevents self-generated itchSemantic proximity Read

Preclinical validation of AAV9-TECPR2 gene therapy in a novel knock-in model of TECPR2-related disorderSemantic proximity Read

Genetic control of the segregation of pain-related sensory neurons innervating the cutaneous versus deep tissues.Semantic proximity Read

Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice.Semantic proximity Read

VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.Semantic proximity Read

Peripheral straightjacket (α2δ Ca 2+ channel subunit) expression is required for neuropathic sensitization in DrosophilaSemantic proximity Read

Immunohistochemical phenotype of sensory neurons associated with sympathetic plexuses in the trigeminal ganglia of adult nerve growth factor transgenic mice.Semantic proximity Read

PIEZO1 transduces mechanical itch in mice.Semantic proximity Read