The COL6A5-p.Glu2272* mutation induces chronic itch in mice

Abstract excerpt

<title>Abstract</title> <p>Pruritus is a common irritating sensation that provokes the desire to scratch. Environmental and genetic factors, altering barrier skin dysfunction, or hypersensitivity of sensory nerves, contribute to the onset of pruritus. However, the itch can become a major burden when it becomes chronic, like in neuropathic itch. The rare Collagen VI alpha 5 (<italic>COL6A5</italic>) gene variant p...

Topics

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• Chronic Disease
• Collagen Type VI
• CRISPR-Cas Systems
• Disease Models, Animal
• Mice
• Mutation
• Pruritus
• Skin

Identifiers and source

Literature Corpus work

40bb7998-8e96-5299-9880-7342bb000042

DOI

10.21203/rs.3.rs-3551110/v1