Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat.

doi:10.1158/1055-9965.EPI-10-0606

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Article

Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2010

Brevik Asgeir, Joshi Amit D, Corral Román, Onland-Moret N Charlotte, Siegmund Kimberly D, Le Marchand Loïc, Baron John A, Martinez Maria Elena, Haile Robert W, Ahnen Dennis J, Sandler Robert S, Lance Peter, Stern Mariana C

Abstract excerpt

BACKGROUND: A diet high in red meat is an established colorectal cancer (CRC) risk factor. Carcinogens generated during meat cooking have been implicated as causal agents and can induce oxidative DNA damage, which elicits repair by the base excision repair (BER) pathway. METHODS: Using a family-based study, we investigated the role of polymorphisms in 4 BER genes (APEX1 Gln51His, Asp148Glu; OGG1 Ser236Cys; PARP...

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Identifiers

PMID: 21037106
DOI: 10.1158/1055-9965.EPI-10-0606
PMCID: PMC3058341

Genes

APEX1
IMPACT
OGG1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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