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Article

DNA repair pathways and mitochondrial DNA mutations in gastrointestinal carcinogenesis.

Clinica chimica acta; international journal of clinical chemistry - 1 May 2007

Basso Daniela, Navaglia Filippo, Fogar Paola, Zambon Carlo-Federico, Greco Eliana, Schiavon Stefania, Fasolo Michela, Stranges Alessia, Falda Alessandra, Padoan Andrea, Fadi Elisa, Pedrazzoli Sergio, Plebani Mario

Abstract excerpt

This work focuses on the main DNA repair pathways, highlighting their role in gastrointestinal carcinogenesis and the role of mitochondrial DNA (mtDNA), mutations being described in several tumor types, including those of the gastrointestinal tract. The mismatch repair (MMR) system is inherently altered in patients with hereditary non-polyposis colorectal cancer, and plays a role in carcinogenesis in a subset of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17397816
DOI: 10.1016/j.cca.2007.02.020

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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