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Article

Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan.

Journal of epidemiology - 1 Jan 2012

Yin Guang, Morita Makiko, Ohnaka Keizo, Toyomura Kengo, Hamajima Nobuyuki, Mizoue Tetsuya, Ueki Takashi, Tanaka Masao, Kakeji Yoshihiro, Maehara Yoshihiko, Okamura Takeshi, Ikejiri Koji, Futami Kitaroh, Yasunami Yohichi, Maekawa Takefumi, Takenaka Kenji, Ichimiya Hitoshi, Terasaka Reiji

Abstract excerpt

BACKGROUND: X-ray cross-complementing group 1 (XRCC1) polymorphisms affect DNA repair capacity and may therefore be of importance in colorectal carcinogenesis. Alcohol consumption, an important risk factor for colorectal cancer, may induce carcinogenesis through DNA damage caused by the toxic effects of alcohol or its metabolites. Therefore, we examined the associations of XRCC1 Arg399Gln, Arg280His, and...

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Source

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Identifiers

PMID: 22186158
DOI: 10.2188/jea.je20110059
PMCID: PMC3798582

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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