Article
Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2010
Fang Shenying, Pinney Susan M, Bailey-Wilson Joan E, de Andrade Mariza A, Li Yafang, Kupert Elena, You Ming, Schwartz Ann G, Yang Ping, Anderson Marshall W, Amos Christopher I
Abstract excerpt
BACKGROUND: Genetic susceptibility for cancer can differ substantially among families. We use trait-related covariates to identify a genetically homogeneous subset of families with the best evidence for linkage in the presence of heterogeneity. METHODS: We performed a genome-wide linkage screen in 93 families. Samples and data were collected by the familial lung cancer recruitment sites of the Genetic...
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