Article
Mps1 phosphorylation sites regulate the function of centrin 2 in centriole assembly.
Molecular biology of the cell - 1 Dec 2010
Yang Ching-Hui, Kasbek Christopher, Majumder Shubhra, Yusof Adlina Mohd, Fisk Harold A
Abstract excerpt
The nondegradable Mps1(Δ12/13) protein drives centriole overproduction, suggesting that Mps1 phosphorylates a subset of centrosomal proteins to drive the assembly of new centrioles. Here we identify three Mps1 phosphorylation sites within the centriolar protein Centrin 2 (Cetn2). Although centrioles can be assembled in the absence of Cetn2, centriole assembly is attenuated in the absence of Cetn2. While wild-type...
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