Separation-of-function MCPH-associated mutations in CPAP affect centriole number and length.

Abstract excerpt

Centrioles are microtubule-based cylindrical ultrastructures characterized by their definite size and robustness. The molecular capping protein, CPAP (also known as CENPJ) engages its N-terminal region with the centriole microtubules to regulate their length. Nevertheless, the conserved C-terminal glycine-rich G-box of CPAP, which interacts with the centriole inner cartwheel protein STIL, is frequently mutated in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Cycle
• Share to Cell Cycle Proteins
• Share to Centrioles