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Article

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.

Nature communications - 30 Apr 2018

Liu Yi, Gupta Gagan D, Barnabas Deepak D, Agircan Fikret G, Mehmood Shahid, Wu Di, Coyaud Etienne, Johnson Christopher M, McLaughlin Stephen H, Andreeva Antonina, Freund Stefan M V, Robinson Carol V, Cheung Sally W T, Raught Brian, Pelletier Laurence, van Breugel Mark

Abstract excerpt

Centrosomes are required for faithful chromosome segregation during mitosis. They are composed of a centriole pair that recruits and organizes the microtubule-nucleating pericentriolar material. Centriole duplication is tightly controlled in vivo and aberrations in this process are associated with several human diseases, including cancer and microcephaly. Although factors essential for centriole assembly, such as...

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Share to Centrioles
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

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Share to Protein Conformation, alpha-Helical

Share to Protein Conformation, beta-Strand

Share to Protein Interaction Domains and Motifs

Source

Open in PubMed Open full text

Identifiers

PMID: 29712910
DOI: 10.1038/s41467-018-04122-x
PMCID: PMC5928214

Genes

STIL
PLK4
CEP85

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.PMID 29712910Read ↗

The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.Semantic proximity Read ↗

Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on CancerSemantic proximity Read ↗

STIL microcephaly mutations interfere with APC/C-mediated degradation and cause centriole amplification.Semantic proximity Read ↗

Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle.Semantic proximity Read ↗

Separation-of-function MCPH-associated mutations in CPAP affect centriole number and length.Semantic proximity Read ↗

GCP6 is a substrate of Plk4 and required for centriole duplicationSemantic proximity Read ↗

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.Semantic proximity Read ↗

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PLK4: a link between centriole biogenesis and cancerSemantic proximity Read ↗

The Chromatin Remodeling Protein CHD-1 and the EFL-1/DPL-1 Transcription Factor Cooperatively Down Regulate CDK-2 to Control SAS-6 Levels and Centriole NumberSemantic proximity Read ↗

PLK4 homodimerization is required for CEP152 centrosome localization and spindle organizationSemantic proximity Read ↗

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