Article
Pesticide use modifies the association between genetic variants on chromosome 8q24 and prostate cancer.
Cancer research - 15 Nov 2010
Koutros Stella, Beane Freeman Laura E, Berndt Sonja I, Andreotti Gabriella, Lubin Jay H, Sandler Dale P, Hoppin Jane A, Yu Kai, Li Qizhai, Burdette Laura A, Yuenger Jeffrey, Yeager Meredith, Alavanja Michael C R
Abstract excerpt
Genome-wide association studies have identified 8q24 region variants as risk factors for prostate cancer. In the Agricultural Health Study, a prospective study of licensed pesticide applicators, we observed increased prostate cancer risk with specific pesticide use among those with a family history of prostate cancer. Thus, we evaluated the interaction among pesticide use, 8q24 variants, and prostate cancer risk....
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