Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer.

doi:10.1158/1055-9965.EPI-12-1454

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Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2013

Karami Sara, Andreotti Gabriella, Koutros Stella, Barry Kathryn Hughes, Moore Lee E, Han Summer, Hoppin Jane A, Sandler Dale P, Lubin Jay H, Burdette Laurie A, Yuenger Jeffrey, Yeager Meredith, Freeman Laura E Beane, Blair Aaron, Alavanja Michael C R

Abstract excerpt

BACKGROUND: Vitamin D and its metabolites are believed to impede carcinogenesis by stimulating cell differentiation, inhibiting cell proliferation, and inducing apoptosis. Certain pesticides have been shown to deregulate vitamin D's anticarcinogenic properties. We hypothesize that certain pesticides may be linked to prostate cancer via an interaction with vitamin D genetic variants. METHODS: We evaluated...

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PMID: 23833127
DOI: 10.1158/1055-9965.EPI-12-1454
PMCID: PMC3773544

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IMPACT
RXRB
VDR

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