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Article

Dexamethasone promotes hypertension by allele-specific regulation of the human angiotensinogen gene.

The Journal of biological chemistry - 27 Feb 2015

Pandey Varunkumar G, Jain Sudhir, Rana Anita, Puri Nitin, Arudra Sri Krishna C, Mopidevi Brahmaraju, Kaw Meenakshi, Nasjletti Alberto, Kumar Ashok

Abstract excerpt

The human angiotensinogen (hAGT) gene has polymorphisms in its 2.5-kb promoter that form two haplotype (Hap) blocks: -6A/G (-1670A/G, -1562C/T, and -1561T/C) and -217A/G (-532T/C, -793A/G, -1074T/C, and -1178G/A). Hap -6A/-217A is associated with human hypertension, whereas Hap -6G/-217G reduces cardiovascular risk. Hap -6A/-217A has increased promoter activity with enhanced transcription factor binding,...

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Identifiers

PMID: 25568318
DOI: 10.1074/jbc.M114.601922
PMCID: PMC4342485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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