Article
A haplotype of angiotensinogen gene that is associated with essential hypertension increases its promoter activity in adipocytes.
Vascular pharmacology - 1 Jan 2006
Li Yanna, Jain Sudhir, Patil Sai, Kumar Ashok
Abstract excerpt
Obesity is associated with hypertension and other cardiovascular diseases especially in the African-American population. Human angiotensinogen (AGT) gene has seven single nucleotide polymorphisms (SNPs) in 1.2 kb region of its promoter. Recent studies have shown that variant -217A is associated with hypertension in African-American and Chinese population. Nucleotide sequence of the hAGT gene has shown that...
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