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Mitochondrial transcription factor A (TFAM) polymorphisms and risk of late-onset Alzheimer's disease in Han Chinese.

Brain research - 12 Jan 2011

Zhang Qun, Yu Jin-Tai, Wang Ping, Chen Wei, Wu Zhong-Chen, Jiang Hong, Tan Lan

Abstract excerpt

Chronic mitochondria DNA (mtDNA) damage and mitochondrial dysfunction induced by increased reactive oxygen species (ROS) have been proved to contribute to the development of Alzheimer's disease (AD). Mitochondrial transcription factor A (TFAM) plays an important role in the maintenance of mtDNA integrity. Recently, some studies suggested two single nucleotide polymorphisms (SNPs) (rs1937 and rs2306604) in the...

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Identifiers

PMID: 20977898
DOI: 10.1016/j.brainres.2010.10.074

Genes

TFAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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