Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial transcription factor A (TFAM) rs1937 and AP endonuclease 1 (APE1) rs1130409 alleles are associated with reduced cognitive performance.

Neuroscience letters - 3 Apr 2017

Lillenes Meryl S, Støen Mari, Günther Clara-Cecilie, Selnes Per, Stenset Vidar T V, Espeseth Thomas, Reinvang Ivar, Fladby Tormod, Tønjum Tone

Abstract excerpt

Mitochondrial dysfunction and DNA damage is intimately connected to ageing and neurodegeneration, including Alzheimer's disease (AD). A particular culprit in this context is oxidative stress, which is a result of increased reactive oxygen species (ROS) due to hyperactive or dysfunctional mitochondria and/or reduced DNA repair capacity. Base excision repair (BER) is the major pathway for repairing oxidative damage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Cognition Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to DNA-Directed DNA Polymerase

Share to DNA Polymerase gamma

Share to Mitochondrial Proteins

Share to Reactive Oxygen Species

Share to tau Proteins

Source

Identifiers

PMID: 28242328
DOI: 10.1016/j.neulet.2017.02.062

Genes

TFAM
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial transcription factor A (TFAM) rs1937 and AP endonuclease 1 (APE1) rs1130409 alleles are associated with reduced cognitive performance.PMID 28242328Read ↗

Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s diseaseSemantic proximity Read ↗

Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease.Semantic proximity Read ↗

Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's DiseaseSemantic proximity Read ↗

Variants of Base Excision Repair Genes MUTYH , PARP1 and XRCC1 in Alzheimer's Disease Risk.Semantic proximity Read ↗

Associations between DNA Damage, DNA Base Excision Repair Gene Variability and Alzheimer's Disease Risk.Semantic proximity Read ↗

Recent developments in the role of DNA damage response and understanding its implications for new therapeutic approaches in Alzheimer's diseaseSemantic proximity Read ↗

Epigenetics of Alzheimer’s DiseaseSemantic proximity Read ↗

Mitochondrial transcription factor A (TFAM) polymorphisms and risk of late-onset Alzheimer's disease in Han Chinese.Semantic proximity Read ↗

Mitochondrial DNA sequence variation associated with dementia and cognitive function in the elderly.Semantic proximity Read ↗

Mitochondrial DNA and Alzheimer's Disease: A First Case-control Study of the Tunisian PopulationSemantic proximity Read ↗

Mitochondria and Alzheimer’s Disease: the Role of Mitochondrial Genetic VariationSemantic proximity Read ↗

DNA damage and repair in Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.