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Article

Mitochondrial transcription factor A (TFAM) gene variation and risk of late-onset Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Apr 2008

Alvarez Victoria, Corao Ana I, Alonso-Montes Cristina, Sánchez-Ferrero Elena, De Mena Lorena, Morales Blanca, García-Castro Mónica, Coto Eliecer

Abstract excerpt

Impaired mitochondrial function and an increased number of mutations in mitochondrial DNA (mtDNA) has been found in brains of patients with late-onset Alzheimer's disease (LOAD). The TFAM-gene encodes the mitochondrial transcription factor A, a protein that controls the transcription, replication, damage sensing, and repair of mtDNA. TFAM is on human chromosome region 10q21.1, where a locus for LOAD has been...

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Identifiers

PMID: 18430995
DOI: 10.3233/jad-2008-13305

Genes

TFAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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