Article
IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma.
BMC gastroenterology - 26 Oct 2010
White Colin D, Khurana Hema, Gnatenko Dmitri V, Li Zhigang, Odze Robert D, Sacks David B, Schmidt Valentina A
Abstract excerpt
BACKGROUND: IQGAP1 and IQGAP2 are homologous members of the IQGAP family of scaffold proteins. Accumulating evidence implicates IQGAPs in tumorigenesis. We recently reported that IQGAP2 deficiency leads to the development of hepatocellular carcinoma (HCC) in mice. In the current study we extend these findings, and investigate IQGAP1 and IQGAP2 expression in human HCC. METHODS: IQGAP1 and IQGAP2 protein expression...
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