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Article

IQGAP1 modulates activation of B-Raf.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2007

Ren Jian-Guo, Li Zhigang, Sacks David B

Abstract excerpt

IQGAP1 modulates several cellular functions, including cell-cell adhesion, transcription, cytoskeletal architecture, and selected signaling pathways. We previously documented that IQGAP1 binds ERK and MAPK kinase (MEK) and regulates EGF-stimulated MEK and ERK activity. Here we characterize the interaction between IQGAP1 and B-Raf, the molecule immediately upstream of MEK in the Ras/MAPK signaling cascade. B-Raf...

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Identifiers

PMID: 17563371
DOI: 10.1073/pnas.0611308104
PMCID: PMC1965536

Genes

IQGAP1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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