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Article

Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent.

Molecular and cellular biology - 1 Mar 2008

Schmidt Valentina A, Chiariello Carmine S, Capilla Encarnación, Miller Frederick, Bahou Wadie F

Abstract excerpt

IQGAPs are multidomain scaffolding proteins that integrate Rho GTPase and Ca2+/calmodulin signals with cell adhesive and cytoskeletal reorganizational events. Targeted disruption of the murine Iqgap2 gene resulted in the age-dependent development of apoptosis and hepatocellular carcinoma (HCC), characterized by the overexpression of IQGAP1, the loss of membrane E-cadherin expression, the cytoplasmic translocation...

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Source

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Identifiers

PMID: 18180285
DOI: 10.1128/MCB.01090-07
PMCID: PMC2258764

Genes

IQGAP1
IQGAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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