Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IQGAP1 Stimulates Proliferation and Enhances Tumorigenesis of Human Breast Epithelial Cells

3 Nov 2007

Abstract excerpt

The scaffold protein IQGAP1 integrates signaling pathways and participates in diverse cellular activities. IQGAP1 is overexpressed in a number of human solid neoplasms, but its functional role in tumorigenesis has not been previously evaluated. Here we report that IQGAP1 contributes to neoplastic transformation of human breast epithelial cells. The amount of IQGAP1 in breast carcinoma is greater than that in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Genomics and Chromatin Dynamics
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17981797
DOI: 10.1074/jbc.m708466200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IQGAP1 Stimulates Proliferation and Enhances Tumorigenesis of Human Breast Epithelial CellsPMID 17981797Read ↗

Role of IQGAP1 in CarcinogenesisSemantic proximity Read ↗

IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesisSemantic proximity Read ↗

IQGAP1 Protein Binds Human Epidermal Growth Factor Receptor 2 (HER2) and Modulates Trastuzumab ResistanceSemantic proximity Read ↗

A PI3K/AKT Scaffolding Protein, IQ Motif–Containing GTPase Associating Protein 1 (IQGAP1), Promotes Head and Neck CarcinogenesisSemantic proximity Read ↗

IQGAP1 modulates activation of B-Raf.Semantic proximity Read ↗

Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro.Semantic proximity Read ↗

Role of IQGAP1 in Head and Neck CarcinogenesisSemantic proximity Read ↗

IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma.Semantic proximity Read ↗

Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancersSemantic proximity Read ↗

Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent.Semantic proximity Read ↗

LncRNA PDCD4-AS1 alleviates triple negative breast cancer by increasing expression of IQGAP2 via miR-10b-5pSemantic proximity Read ↗

IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.