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Article

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase is a distant IPK member with a singular inositide binding site for axial 2-OH recognition.

Proceedings of the National Academy of Sciences of the United States of America - 25 May 2010

González Beatriz, Baños-Sanz Jose Ignacio, Villate Maider, Brearley Charles Alistair, Sanz-Aparicio Julia

Abstract excerpt

Inositol phosphates (InsPs) are signaling molecules with multiple roles in cells. In particular (InsP(6)) is involved in mRNA export and editing or chromatin remodeling among other events. InsP(6) accumulates as mixed salts (phytate) in storage tissues of plants and plays a key role in their physiology. Human diets that are exclusively grain-based provide an excess of InsP(6) that, through chelation of metal...

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Identifiers

PMID: 20453199
DOI: 10.1073/pnas.0912979107
PMCID: PMC2906834

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