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Article

Region of difference 2 contributes to virulence of Mycobacterium tuberculosis.

Infection and immunity - 1 Jan 2011

Kozak Robert A, Alexander David C, Liao Reiling, Sherman David R, Behr Marcel A

Abstract excerpt

Mycobacterium bovis BCG strains are live, attenuated vaccines generated through decades of in vitro passage. Because in vitro growth does not select for interaction with the host, it has been hypothesized that genetic loci lost from BCG code for virulence determinants that are dispensable for growth in the laboratory, as exemplified by Region of Difference 1 (RD1), which was lost during the original derivation of...

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Identifiers

PMID: 20974821
DOI: 10.1128/IAI.00824-10
PMCID: PMC3019914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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