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Article

Divergence of immunologic and protective responses of different BCG strains in a murine model.

Vaccine - 4 Feb 2011

Kozak R, Behr M A

Abstract excerpt

The ongoing evolution of BCG after its introduction in 1921 resulted in strains that differ genetically and phenotypically. Based on a genomic deletion (Region of Difference 2 or RD2) that occurred between 1927 and 1931, BCG strains can be sub-classified by the presence or absence of RD2. The existence of other mutations that distinguish BCG strains precludes simple comparison of RD2-positive and RD2-negative BCG...

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Identifiers

PMID: 21184855
DOI: 10.1016/j.vaccine.2010.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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