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Article

Genetic diversity of immune-related antigens in Region of Difference 2 of Mycobacterium tuberculosis strains.

Tuberculosis (Edinburgh, Scotland) - 1 May 2017

Jiang Yi, Liu Haican, Wang Xuezhi, Xiao Shiqi, Li Machao, Li Guilian, Zhao Lili, Zhao Xiuqin, Dou Xiangfeng, Wan Kanglin

Abstract excerpt

Region of Difference 2 (RD2) was lost during the ongoing propagation of BCG between 1927 and 1931, a time that coincides with reports of the ongoing attenuation of the vaccine. Some data demonstrate that RD2 plays a role in mycobacterial virulence, and that its deletion from Mycobacterium tuberculosis leads to a decrease in bacterial growth in both a macrophage and a murine model. Human T-cell epitopes of M....

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Source

Identifiers

PMID: 28454644
DOI: 10.1016/j.tube.2016.05.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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