Article
Variable Virulence and Efficacy of BCG Vaccine Strains in Mice and Correlation With Genome Polymorphisms.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2016
Zhang Lu, Ru Huan-Wei, Chen Fu-Zeng, Jin Chun-Yan, Sun Rui-Feng, Fan Xiao-Yong, Guo Ming, Mai Jun-Tao, Xu Wen-Xi, Lin Qing-Xia, Liu Jun
Abstract excerpt
Bacille Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis, is the only vaccine available for tuberculosis (TB) control. However, BCG is not an ideal vaccine and has two major limitations: BCG exhibits highly variable effectiveness against the development of TB both in pediatric and adult populations and can cause disseminated BCG disease in immunocompromised individuals. BCG comprises a number of...
Topics
- Animals
- BCG Vaccine
- Chromosome Duplication
- Genetic Variation
- Mice
- Mice, Inbred BALB C
- Mice, SCID
- Mycobacterium bovis
- Sequence Deletion
- Survival Analysis