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Article

Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis.

Journal of bacteriology - 1 Mar 1996

Mahairas G G, Sabo P J, Hickey M J, Singh D C, Stover C K

Abstract excerpt

The live attenuated bacillus Calmette-Guérin (BCG) vaccine for the prevention of disease associated with Mycobacterium tuberculosis was derived from the closely related virulent tubercle bacillus, Mycobacterium bovis. Although the BCG vaccine has been one of the most widely used vaccines in the world for over 40 years, the genetic basis of BCG's attenuation has never been elucidated. We employed subtractive...

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Identifiers

PMID: 8631702
DOI: 10.1128/jb.178.5.1274-1282.1996
PMCID: PMC177799

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