Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner.

The Journal of biological chemistry - 19 Sept 2003

Lai KehDih, Harnish Douglas C, Evans Mark J

Abstract excerpt

Hormonal status can influence diverse metabolic pathways. Small heterodimer partner (SHP) is an orphan nuclear receptor that can modulate the activity of several transcription factors. Estrogens are here shown to directly induce expression of the SHP in the mouse and rat liver and in human HepG2 cells. SHP is rapidly induced within 2 h following treatment of mice with ethynylestradiol (EE) or the estrogen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol 7-alpha-Hydroxylase
Share to Dimerization
Share to Estradiol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Phenols

Share to Pyrazoles

Share to Receptors, Cytoplasmic and Nuclear

Share to Receptors, Estrogen

Source

Identifiers

PMID: 12842887
DOI: 10.1074/jbc.M303913200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner.PMID 12842887Read ↗

Role of nuclear receptor SHP in metabolism and cancer.Semantic proximity Read ↗

Dual Mechanisms for Repression of the Monomeric Orphan Receptor Liver Receptor Homologous Protein-1 by the Orphan Small Heterodimer PartnerSemantic proximity Read ↗

The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptors.Semantic proximity Read ↗

Synergistic regulation of the mouse orphan nuclear receptor SHP gene promoter by CLOCK-BMAL1 and LRH-1.Semantic proximity Read ↗

Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner.Semantic proximity Read ↗

Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.Semantic proximity Read ↗

Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in miceSemantic proximity Read ↗

Transcriptional Regulation of Dehydroepiandrosterone Sulfotransferase (SULT2A1) by Estrogen-Related Receptor αSemantic proximity Read ↗

Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1.Semantic proximity Read ↗

Transcriptional Regulation of the Human Sterol 12α-Hydroxylase Gene (CYP8B1)Semantic proximity Read ↗

Regulation of the Human Hydroxysteroid Sulfotransferase (SULT2A1) by RORα and RORγ and Its Potential Relevance to Human Liver DiseasesSemantic proximity Read ↗

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.