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Article

Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease.

American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2013

Smalling Rana V, Delker Don A, Zhang Yuxia, Nieto Natalia, McGuiness Michael S, Liu Shuanghu, Friedman Scott L, Hagedorn Curt H, Wang Li

Abstract excerpt

The molecular mechanisms behind human liver disease progression to cirrhosis remain elusive. Nuclear receptor small heterodimer partner (SHP/Nr0b2) is a hepatic tumor suppressor and a critical regulator of liver function. SHP expression is diminished in human cirrhotic livers, suggesting a regulatory role in human liver diseases. The goal of this study was to identify novel SHP-regulated genes that are involved...

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Identifiers

PMID: 23812039
DOI: 10.1152/ajpgi.00077.2013
PMCID: PMC3761248

Genes

SPARC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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