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Article

Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?

6 Jan 2016

Abstract excerpt

Nuclear receptors (NR) are ligand-modulated transcription factors that play diverse roles in cell differentiation, development, proliferation, and metabolism and are associated with numerous liver pathologies such as cancer, steatosis, inflammation, fibrosis, cholestasis, and xenobiotic/drug-induced liver injury. The network of target proteins associated with NRs is extremely complex, comprising coregulators,...

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PMID: 26738480
DOI: 10.1146/annurev-pharmtox-010715-103209

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