Article
Internal translation initiation stimulates expression of the ARF/core+1 open reading frame of HCV genotype 1b.
Virus research - 1 Jan 2011
Boumlic Anissa, Vassilaki Niki, Dalagiorgou Georgia, Kochlios Emmanouil, Kakkanas Athanassios, Georgopoulou Urania, Markoulatos Panagiotis, Orfanoudakis Georges, Mavromara Penelope
Abstract excerpt
The hepatitis C virus possesses an alternative open reading frame overlapping the Core gene, whose products are referred to as Core+1 or alternative reading frame (ARF) or F protein(s). Extensive studies on genotype HCV-1a demonstrated that ribosomal frameshifting supports the synthesis of core+1 protein, when ten consecutive As are present within core codons 9-11 whereas, in the absence of this motif, expression...
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