Article
Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis -Acting RNA Elements in Viral RNA Translation and Replication
18 Sept 2008
Abstract excerpt
Four conserved RNA stem-loop structures designated SL47, SL87, SL248, and SL443 have been predicted in the hepatitis C virus (HCV) core encoding region. Moreover, alternative translation products have been detected from a reading frame overlapping the core gene (core+1/ARFP/F). To study the importance of the core+1 frame and core-RNA structures for HCV replication in cell culture and in vivo, a panel of core gene...
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