Article
Synonymous mutations in the core gene are linked to unusual serological profile in hepatitis C virus infection.
PloS one - 6 Jan 2011
Budkowska Agata, Kakkanas Athanassios, Nerrienet Eric, Kalinina Olga, Maillard Patrick, Horm Srey Viseth, Dalagiorgou Geena, Vassilaki Niki, Georgopoulou Urania, Martinot Michelle, Sall Amadou Alpha, Mavromara Penelope
Abstract excerpt
The biological role of the protein encoded by the alternative open reading frame (core+1/ARF) of the Hepatitis C virus (HCV) genome remains elusive, as does the significance of the production of corresponding antibodies in HCV infection. We investigated the prevalence of anti-core and anti-core+1/ARFP antibodies in HCV-positive blood donors from Cambodia, using peptide and recombinant protein-based ELISAs. We...
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