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The major form of hepatitis C virus alternate reading frame protein is suppressed by core protein expression

16 Mar 2008

Abstract excerpt

Hepatitis C virus (HCV) is a human RNA virus encoding 10 proteins in a single open reading frame. In the +1 frame, an 'alternate reading frame' (ARF) overlaps with the core protein-encoding sequence and encodes the ARF protein (ARFP). Here, we investigated the molecular regulatory mechanisms of ARFP expression in HCV target cells. Chimeric HCV-luciferase reporter constructs derived from the infectious HCV...

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PMID: 18400784
DOI: 10.1093/nar/gkn111

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