Article
Methods of detection of single base substitutions in clinical genetic practice.
Molecular biology & medicine - 1 Oct 1990
Forrest S, Cotton R G
Abstract excerpt
The ability to diagnose human diseases at the DNA level has become possible because of a rapid development in DNA technology, particularly in the area of detection of single base substitutions. Mutations in the genomic DNA of a particular gene may be inferred indirectly using linkage analysis and restriction fragment length polymorphisms. However, direct detection of the mutation is the more favourable approach....
Topics
- Base Composition
- Genetic Carrier Screening
- Humans
- Mutation
- Prenatal Diagnosis