Article
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
Nature genetics - 1 Nov 2010
Ellinghaus Eva, Ellinghaus David, Stuart Philip E, Nair Rajan P, Debrus Sophie, Raelson John V, Belouchi Majid, Fournier Hélène, Reinhard Claudia, Ding Jun, Li Yun, Tejasvi Trilokraj, Gudjonsson Johann, Stoll Stefan W, Voorhees John J, Lambert Sylviane, Weidinger Stephan, Eberlein Bernadette, Kunz Manfred, Rahman Proton, Gladman Dafna D, Gieger Christian, Wichmann H Erich, Karlsen Tom H, Mayr Gabriele, Albrecht Mario, Kabelitz Dieter, Mrowietz Ulrich, Abecasis Gonçalo R, Elder James T, Schreiber Stefan, Weichenthal Michael, Franke Andre
Abstract excerpt
Psoriasis is a multifactorial skin disease characterized by epidermal hyperproliferation and chronic inflammation, the most common form of which is psoriasis vulgaris (PsV). We present a genome-wide association analysis of 2,339,118 SNPs in 472 PsV cases and 1,146 controls from Germany, with follow-up of the 147 most significant SNPs in 2,746 PsV cases and 4,140 controls from three independent replication panels....
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