Article
Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase α1s/sα2s/s Mouse Model of High Affinity for Cardiotonic Steroids.
International journal of molecular sciences - 27 Mar 2021
Marck Pauline V, Pessoa Marco T, Xu Yunhui, Kutz Laura C, Collins Dominic M, Yan Yanling, King Cierra, Wang Xiaoliang, Duan Qiming, Cai Liquan, Xie Jeffrey X, Lingrel Jerry B, Xie Zijian, Tian Jiang, Pierre Sandrine V
Abstract excerpt
The Na/K-ATPase is the specific receptor for cardiotonic steroids (CTS) such as ouabain and digoxin. At pharmacological concentrations used in the treatment of cardiac conditions, CTS inhibit the ion-pumping function of Na/K-ATPase. At much lower concentrations, in the range of those reported for endogenous CTS in the blood, they stimulate hypertrophic growth of cultured cardiac myocytes through initiation of a...
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