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Article

Hypertension from chronic central sodium chloride in mice is mediated by the ouabain-binding site on the Na,K-ATPase α₂-isoform.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2011

Van Huysse James W, Dostanic Iva, Lingrel Jerry B, Hou Xiaohong, Wu Hengwei

Abstract excerpt

A chronic increase in the concentration of sodium chloride in the cerebrospinal fluid (CSF) (↑CSF [NaCl]) appears to be critically important for the development of salt-dependent hypertension. In agreement with this concept, increasing CSF [NaCl] chronically by intracerebroventricular (icv) infusion of NaCl-rich artificial CSF (aCSF-HiNaCl) in rats produces hypertension by the same mechanisms (i.e.,...

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Identifiers

PMID: 21856907
DOI: 10.1152/ajpheart.01216.2010
PMCID: PMC3213960

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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