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Article

Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes.

Journal of molecular and cellular cardiology - 1 Jul 2011

Dhandapany Perundurai S, Fabris Frank, Tonk Rahul, Illaste Ardo, Karakikes Ioannis, Sorourian Mehran, Sheng Jipo, Hajjar Roger J, Tartaglia Marco, Sobie Eric A, Lebeche Djamel, Gelb Bruce D

Abstract excerpt

RAS activation is implicated in physiologic and pathologic cardiac hypertrophy. Cross-talk between the Ras and calcineurin pathways, the latter also having been implicated in cardiac hypertrophy, has been suspected for pathologic hypertrophy. Our recent discovery that germ-line mutations in RAF1, which encodes a downstream RAS effector, cause Noonan and LEOPARD syndromes with a high prevalence of hypertrophic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21440552
DOI: 10.1016/j.yjmcc.2011.03.001
PMCID: PMC3103595

Genes

RAF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes.PMID 21440552Read ↗

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