Article
Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes.
Journal of molecular and cellular cardiology - 1 Jul 2011
Dhandapany Perundurai S, Fabris Frank, Tonk Rahul, Illaste Ardo, Karakikes Ioannis, Sorourian Mehran, Sheng Jipo, Hajjar Roger J, Tartaglia Marco, Sobie Eric A, Lebeche Djamel, Gelb Bruce D
Abstract excerpt
RAS activation is implicated in physiologic and pathologic cardiac hypertrophy. Cross-talk between the Ras and calcineurin pathways, the latter also having been implicated in cardiac hypertrophy, has been suspected for pathologic hypertrophy. Our recent discovery that germ-line mutations in RAF1, which encodes a downstream RAS effector, cause Noonan and LEOPARD syndromes with a high prevalence of hypertrophic...
Topics
- Adenoviridae
- Animals
- Animals, Newborn
- Calcineurin
- Calcium Signaling
- Cardiomegaly
- Cardiomyopathy, Hypertrophic
- Cyclosporine
- Disease Models, Animal
- LEOPARD Syndrome