Article
F463L increases the potential of dofetilide on human ether-a-go-go-related gene (hERG) channels.
Microscopy research and technique - 1 Jun 2018
Cheng Gong, Wu Jine, Han Wenqi, Sun Chaofeng
Abstract excerpt
Mutations in genes related to long QT syndrome (LQTS) is recognized as an independent risk of drug-induced LQTS. We previously screened a mutation F463L in a Chinese patient with LQT2, syncope, and epilepsy. Here, we planned to illustrate how F463L influences the action of dofetilide on hERG channels. F463L-hERG plasmids were transfected into the stable Human Embryonic Kidney 293 (HEK293) cells expressing WT-hERG...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.