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Article

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.

British journal of pharmacology - 1 Nov 2006

Rajamani S, Eckhardt L L, Valdivia C R, Klemens C A, Gillman B M, Anderson C L, Holzem K M, Delisle B P, Anson B D, Makielski J C, January C T

Abstract excerpt

BACKGROUND AND PURPOSE: Fluoxetine (Prozac) is a widely prescribed drug in adults and children, and it has an active metabolite, norfluoxetine, with a prolonged elimination time. Although uncommon, Prozac causes QT interval prolongation and arrhythmias; a patient who took an overdose of Prozac exhibited a prolonged QT interval (QTc 625 msec). We looked for possible mechanisms underlying this clinical finding by...

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Identifiers

PMID: 16967046
DOI: 10.1038/sj.bjp.0706892
PMCID: PMC2014667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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