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Article

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

Journal of proteome research - 5 Feb 2010

Freibaum Brian D, Chitta Raghu K, High Anthony A, Taylor J Paul

Abstract excerpt

TDP-43 is a highly conserved and ubiquitously expressed member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family of proteins. Recently, TDP-43 was shown to be a major disease protein in the ubiquitinated inclusions characteristic of most cases of amyotrophic lateral sclerosis (ALS), tau-negative frontotemporal lobar degeneration (FTLD), and inclusion body myopathy. In these diseases, TDP-43 is...

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Identifiers

PMID: 20020773
DOI: 10.1021/pr901076y
PMCID: PMC2897173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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