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Article

TDP‐43 is recruited to stress granules in conditions of oxidative insult

16 Sept 2009

Abstract excerpt

Transactive response DNA-binding protein 43 (TDP-43) forms abnormal ubiquitinated and phosphorylated inclusions in brain tissues from patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. TDP-43 is a DNA/RNA-binding protein involved in RNA processing, such as transcription, pre-mRNA splicing, mRNA stabilization and transport to dendrites. We found that in response to oxidative...

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PMID: 19765185
DOI: 10.1111/j.1471-4159.2009.06383.x

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