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Article

TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress.

Journal of neurochemistry - 1 Jul 2013

Higashi Shinji, Kabuta Tomohiro, Nagai Yoshitaka, Tsuchiya Yukihiro, Akiyama Haruhiko, Wada Keiji

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) has emerged as an important contributor to amyotrophic lateral sclerosis and frontotemporal lobar degeneration. To understand the physiological roles of TDP-43 in the complex translational regulation mechanisms, we exposed cultured cells to oxidative stress induced by sodium arsenite (ARS) for different periods of time, leading to non-lethal or sublethal injury. Polysome...

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Identifiers

PMID: 23398327
DOI: 10.1111/jnc.12194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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