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The HSV-1 Exonuclease, UL12, Stimulates Recombination by a Single Strand Annealing Mechanism

9 Aug 2012

Abstract excerpt

Production of concatemeric DNA is an essential step during HSV infection, as the packaging machinery must recognize longer-than-unit-length concatemers; however, the mechanism by which they are formed is poorly understood. Although it has been proposed that the viral genome circularizes and rolling circle replication leads to the formation of concatemers, several lines of evidence suggest that HSV DNA replication...

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PMID: 22912580
DOI: 10.1371/journal.ppat.1002862

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