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Article

EZH2 expands breast stem cells through activation of NOTCH1 signaling

10 Feb 2014

Abstract excerpt

Breast cancer is the second-leading cause of cancer-related deaths in women, but the details of how it begins remain elusive. Increasing evidence supports the association of aggressive triple-negative (TN) breast cancer with heightened expression of the Polycomb group protein Enhancer of Zeste Homolog 2 (EZH2) and increased tumor-initiating cells (TICs). However, mechanistic links between EZH2 and TICs are...

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PMID: 24516139
DOI: 10.1073/pnas.1308953111

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