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Article

Other ways to skin a cat: activating SREBP without Scap.

Fly - 1 Jan 2000

Ozdemir Cafer, Rawson Robert B

Abstract excerpt

The sterol regulatory element binding protein (SREBP) pathway plays a central role in the global regulation of lipid homeostasis. SREBPs are membrane-bound transcription factors whose proteolytic activation is regulated by cellular lipid levels; when demand for lipid rises, SREBP travels from the endoplasmic reticulum to the Golgi apparatus where it is cleaved by two distinct proteases. Cleavage releases the...

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Identifiers

PMID: 20935466
DOI: 10.4161/fly.5.1.13475
PMCID: PMC3052868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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